Molecular Interactions & Analysis in Organic Chemistry


Unit code: CHEM40422 Teaching period(s): Semester 2
Credit Rating: 10 Available as a free choice unit?: N
Unit level: Level 4 Offered by School of Chemistry

Requisites

None

Aims

The course unit unit aims to:

  • Provide an understanding of supramolecular chemistry, its importance in chemistry and biology, and describe some applications in modern chemical research.
  • Introduce some advanced techniques of high-field NMR spectroscopy, with emphasis on their applications in solving structural problems.
  • Introduction to organic self-assembled monolayers and its application in surface chemistry, together with the analytical methods employed in surface chemistry for their characterisation.
  • Provide an understanding of electron transfer, its importance in chemistry and biology, and its application in synthetic organic chemistry.

Overview

Supramolecular Chemistry (SJ Webb, 8 lectures)

  • Types of supramolecular interactions
  • Quantifying supramolecular interactions
  • Applications of supramolecular chemistry

Applied NMR Spectroscopy (TW Wallace, 4 lectures)

  • Data acquisition, processing and analysis
  • Homo- and heteronuclear coupling in 1H and 13C NMR spectra
  • Through-bond and through-space chemical shift correlation
  • Applications of 2D-NMR spectra (COSY, HMQC, NOESY, etc.)

Surface Chemistry (LS Wong, 4 lectures)

  • Structure and properties of gold-alkylthiolate self-assembled monolayers
  • Structure and properties of alkylsiloxane self-assembled monolayers
  • Surface analysis of self-assembled monolayers
  • Nanolithography of self-assembled monolayers

Electron transfer in organic chemistry (DJ Procter, 8 lectures)

  • Principles of electron transfer
  • Techniques for the study of electron transfer
  • Synthesis using organic and metallic electron transfer reagents

Assessment methods

  • Written exam - 100%

Learning outcomes

Recommended reading

Recommended Reading

  • Organic Chemistry J Clayden, N Greeves, S Warren and P Wothers (Oxford University Press, 2001) ISBN 0198503466
  • Supramolecular Chemistry J W Steed and J L Atwood (Wiley, 2000) ISBN 0471987918
  • Supramolecular Chemistry F VÃgtle (Wiley, 1991) ISBN 047192802X
  • Nuclear Magnetic Resonance (Oxford Chemistry Primer, no. 32) P J Hore (Oxford University Press, 1995) ISBN 9780198556824
  • Basic One-and Two-Dimensional NMR Spectroscopy (4th edition) H Friebolin (Wiley-VCH, 2005) ISBN 3527312331
  • Surface analysis : the principal techniques (2nd edition); JC Vickerman, IS Gilmore (editors); 2nd edition (Wiley, 2009) ISBN 978-0470017647
  • Formation and Structure of Self-Assembled Monolayers. A. Ulman, Chem. Rev. 1996, 96, 1533-1554. DOI: 10.1021/cr9502357
  • Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology. J. C. Love, L. A. Estroff, J. K. Kriebel, R. G. Nuzzo, G. M. Whitesides, Chem. Rev. 2005, 105, 1103-1170. DOI: 10.1021/cr0300789
  • New Approaches to Nanofabrication: Molding, Printing, and Other Techniques. B. D. Gates, Q. Xu, M. Stewart, D. Ryan, C. G. Willson, G. M. Whitesides, Chem. Rev. 2005, 105, 1171-1196. DOI: 10.1021/cr030076o
  • Organic synthesis in two dimensions. T. P. Sullivan, W. T. S. Huck, Eur. J. Org. Chem. 2003, 17-29. DOI: 10.1002/1099-0690(200301)2003:1<17::AID-EJOC17>3.0.CO;2-H
  • Organic Synthesis using Samarium Diiodide: A practical guide, D J Procter, R A Flowers, T Skrydstrup, (RSC Publishing, 2009), ISBN 978-1-84755-110-8

Study hours

  • Assessment written exam - 2 hours
  • Lectures - 24 hours
  • Independent study hours - 74 hours

Teaching staff

Simon Webb - Unit coordinator


Data source is Central CUIP

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