Advanced Magnetic Resonance

Unit code: CHEM40252
Credit Rating: 10
Unit level: Level 4
Teaching period(s): Semester 2
Offered by School of Chemistry
Available as a free choice unit?: N




  • To explain the principles and applications of modern advanced techniques in magnetic resonance and spin chemistry


NMR Diffusion Methods (Dr M Nilsson)

·     Pulsed field gradients and pulsed field gradient stimulated echo experiments.

·     Spatial encoding and diffusional attenuation.

·     Diffusion-ordered spectroscopy (DOSY).

·     Qualitative and quantitative information from NMR diffusion experiments.


Solid-State NMR (Prof M W Anderson)

·     Principles and applications of solid-state NMR.

·     Mechanisms of line-broadening and measurement techniques in the solid state: chemical shift anisotropy; dipolar interaction; quad

Teaching and learning methods

4 sets of 6 lectures on each of the above topics, including workshop material as appropriate. 

Learning outcomes

Learning outcomes

On completing the course, students should:

  • understand the application of the principles of spin dynamics to a wide range of experimental methods and practical applications, including CW EPR, solid state NMR and MR imaging
  • be familiar with the properties and processes determining contrast in magnetic resonance imaging
  • be able to describe the use of NMR as a tool in structural biology and medicine
  • be familiar with the properties and processes determining contrast in magnetic resonance imaging,

Transferable skills and personal qualities

  • Problem-solving skills (unit presents tools of resonance methods and applications are exemplified in the lectures, support material and in assessment)
  • Numeracy (data handling and interpreting of numerical spectroscopic data)
  • Analytical skills (all of the unit)
  • Knowledge gained from spectral analysis, data handling and interpretation using statistical methods will equip the students with advanced analytical skills in physical and biomedical science applications


Assessment methods

  • Written exam - 100%

Recommended reading

Continuous Wave EPR Spectroscopy (Prof D Collison)

  • V. Chechik,  E. Carter, D. Murphy, Electron Paramagnetic Resonance (Oxford Chemistry Primers), OUP, 2016
  • M. C. R. Symons, Chemical and Biochemical Aspects of Electron Spin Resonance Spectroscopy, Van Nostrand Reinhold, 1978
  •  G.R. Eaton, S.S. Eaton, D. Barr, R. Weber, Quantitative EPR, Springer, 2009
  • M. Brustolon, E. Giamello (Eds), Electron Paramagnetic Resonance: A Practitioners Toolkit, Wiley-Blackwell, 2009
  •  F.E. Mabbs, D. Collison, Electron Paramagnetic Resonance of d Transition Metal Compounds, Elsevier, 1992

Solid-State NMR (Prof M W Anderson)

  •   M J Duer, Solid State NMR Spectroscopy: Principles and Applications, OUP 2011

NMR Diffusion Methods (Dr M Nilsson)

  • P T Callaghan, Translational Dynamics and Magnetic Resonance. Principles of Pulsed Gradient Spin Echo NMR, OUP 2011
  •  T.D.W. Claridge, High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 2016
  • J Keeler, Understanding NMR Spectroscopy, Wiley 2011

NMR in Biology (Prof G A Morris)

  •  K Wüthrich, NMR of proteins and nucleic acids, Wiley, 1986
  •  J. Cavanagh et al., Protein NMR spectroscopy: principles and practice, Academic Press, 1996
  • T.D.W. Claridge, High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 2016
  • R. Freeman, Magnetic Resonance in Chemistry and Medicine, Oxford University Press, 2003



Feedback methods

Feedback will be available in the workshop sessions. Past exam questions will be addressed in workshops and the four lecturers will be available to discuss matters with students throughout the course.


Study hours

  • Assessment written exam - 2 hours
  • Lectures - 24 hours
  • Independent study hours - 74 hours

Teaching staff

Michael Anderson - Unit coordinator

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