Professor Douglas Kell: Recent papers on human metabolic systems biology

Professor Douglas Kell has published a number of recent and significant papers on human metabolic systems biology.

Professor Douglas Kell has published a number of recent and significant papers on human metabolic systems biology: one is a consensus version of the curated human metabolic network [1], which makes a variety of accurate predictions regarding inborn errors of metabolism and which metabolites are excreted, while the second [2] covers issues of where target-based drug discovery has failed and what we need to do to replace it. This involves a systems biology approach, phenotypic screening, the recognition of the importance of drug transporters [3], and the need for purposeful polypharmacology.
 
[1] Kell DB: Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening, and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS J 2013: in the press. 
 
[2] Thiele I, Swainston N, Fleming RMT, Hoppe A, Sahoo S, Aurich MK, Haraldsdottír H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Goryanin I, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jones J, Jonsson JJ, Juty N, Keating S, Nookaew I, Novère NL, Malys N, Mazein A, Papin JA, Patel Y, Price ND, Selkov Sr. E, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, Beek HV, Weichart D, Nielsen JB, Westerhoff HV, Kell DB, Mendes P, Palsson BØ: A community-driven global reconstruction of human metabolism. Nature Biotechnol 2013:in the press.
 
[3] Kell DB, Dobson PD, Bilsland E, Oliver SG: The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Disc Today 2013; 18:218-239.

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