Director: Dr Vasudevan Ramesh
Learning objectives
- To understand the NMR experimental parameters which govern the quality of NMR spectra
- To elaborate the principles and experimental methods involved in the acquisition, data processing and interpretation of one- and two-dimensional NMR spectra
- To demonstrate the application of NMR in structure elucidation with examples
Syllabus
- Basic principles of NMR and experimental parameters
- 1H, 13C chemical shifts; multinuclear NMR
- Relationship between the NMR spectrum and molecular structure
- Spin–spin coupling; H-H, C-H coupling constants; Karplus relationship
- Analysis of NMR spectra; nomenclature of spin systems
- Fourier transformation; sensitivity enhancement; nuclear relaxation
- Multipulse NMR techniques; DEPT experiment
- Two-dimensional (2D) NMR; chemical shift correlation (COSY, TOCSY, HMQC and HMBC)
- The Nuclear Overhauser Effect; 1D NOE , 2D NOESY and ROESY
- NMR Applications; Dynamic NMR
- Demonstrate an understanding of the NMR phenomenon and its applications
- Explain the significance of chemical shifts (1H,13C) and their use in functional group identification
- Describe the physical basis of spin-spin coupling
- Exemplify how coupling constants can be used to determine stereochemical relationships
- Show how enhancement of sensitivity takes place due to Fourier transformation
- Explain the utility of multipulse NMR in spectral simplification
- Describe in a simple way how 2D NMR works and the different types of experiments that can be performed
- Rationalise the NOE effect ( 1D and 2D ) to solve organic structural problems
- Demonstrate how NMR can be applied to investigate dynamic effects ( e.g. barriers to rotation)
- Introduction to NMR Spectroscopy by R.J. Abraham, J. Fisher and P.Loftus; J. Wiley & Sons, 1988.
- High Resolution NMR techniques in Organic Chemistry by T.D.W. Claridge; Pergamon, 2009.
- Basic One- and Two-Dimensional NMR Spectroscopy by H. Friebolin ; Wiley & VCH, ; 2004.